(S) -OTS514
(S) -OTS514 is the S enantiomer of OTS514. OTS514 is a highly potent TOPK inhibitor with an IC50 of 2.6 nM. OTS514 strongly suppresses the growth of TOPK-positive cancer cells[1]. OTS514 induces cell cycle arrest and apoptosis[2].
Product Specifications
CAS Number
1338541-25-5
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/s-ots514.html
Solubility
DMSO : 31.43 mg/mL (adjust pH to 3 with 1 M HCL)
Smiles
O=C1NC2=C(C(C3=CC=C([C@H](C)CN)C=C3)=C(O)C=C2C)C4=C1SC=C4
Molecular Formula
C21H20N2O2S
Molecular Weight
364.46
References & Citations
[1]Matsuo Y, et al. TOPK inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition of cytokinesis. Sci Transl Med. 2014 Oct 22;6 (259) :259ra145.|[2]Stefka AT, et al. Potent anti-myeloma activity of the TOPK inhibitor OTS514 in pre-clinical models. Cancer Med. 2020 Jan;9 (1) :324-334.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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