Cyasterone

Cyasterone, a natural EGFR inhibitor, mainly isolated from Ajuga decumbens Thunb (Labiatae) . Cyasterone manifests anti-proliferation effect by induced apoptosis and cell cycle arrests. Cyasterone may serves as a therapeutic anti-tumor agent against human tumors[1].

Product Specifications

CAS Number

[17086-76-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; EGFR

Type

Natural Products

Related Pathways

Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cyasterone.html

Purity

99.58

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@]([C@](C)([C@H](O)C[C@@H]3[C@@H](C)OC([C@H]3C)=O)O)([H])CC[C@@]1(O)C4=CC([C@]5([H])C[C@@H](O)[C@@H](O)C[C@]5(C)[C@@]4([H])CC2)=O

Molecular Formula

C29H44O8

Molecular Weight

520.65

Precautions

H302, H315, H319, H335

References & Citations

[1]Lu X, et al. Anti-proliferation effects, efficacy of cyasterone in vitro and in vivo and its mechanism. Biomed Pharmacother. 2016 Dec;84:330-339.|[2]Lu X, et al. Anti-proliferation effects, efficacy of cyasterone in vitro and in vivo and its mechanism.Biomed Pharmacother. 2016 Dec;84:330-339.