Amphomycin

Amphomycin is a lipopeptide antibiotic that inhibits peptidoglycan synthesis and blocks cell wall development. Amphomycin exhibits potent antibacterial activities against methicillin-resistant S. aureus (MRSA), vancomycin-resistant enterococci (VRE), penicillin-gentamicin-erythromycin-resistant S. pneumonia, and linezolid-quinupristin-dalfopristin-resistant enterococci[1][2][3].

Product Specifications

CAS Number

[1402-82-0]

UNSPSC

12352209

Target

Antibiotic; Bacterial

Type

Peptides

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/amphomycin.html

Purity

96.30

Solubility

10 mM in DMSO

Smiles

O=C([C@]1([H])CCCN1C([C@@H](NC([C@H](NC(CNC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@]2([H])CCCCN2C3=O)=O)[C@H](C)C(O)=O)=O)CC(O)=O)=O)=O)CC(O)=O)=O)=O)[C@@H](C)N)=O)C(C)C)=O)N[C@@H]([C@@H]3NC([C@H](CC(O)=O)NC(C/C=C\CCCCCC(CC)C)=O)=O)C

Molecular Formula

C58H91N13O20

Molecular Weight

1290.42

References & Citations

[1]Singh M, et al. Solid-state NMR characterization of amphomycin effects on peptidoglycan and wall teichoic acid biosyntheses in Staphylococcus aureus. Sci Rep. 2016 Aug 19;6:31757. |[2]Pasetka CJ, et al. Novel antimicrobial lipopeptides with long in vivo half-lives. Int J Antimicrob Agents. 2010 Feb;35 (2) :182-5. |[3]Tanaka H, et al. Amphomycin inhibits phospho-N-acetylmuramyl-pentapeptide translocase in peptidoglycan synthesis of Bacillus. Biochem Biophys Res Commun. 1979 Feb 14;86 (3) :902-8.