UNC2383

UNC2383 is an oligonucleotide enhancer compound. UNC2383 can enhance the efficacy of antisense oligonucleotides (ASOs) and splice-switching oligonucleotides (SSOs) . UNC2383 can be used in research of diseases involving impaired oligonucleotide delivery, such as cystic fibrosis[1][2][3].

Product Specifications

CAS Number

[2123481-48-9]

UNSPSC

12352005

Target

Biochemical Assay Reagents

Type

Oligonucleotides

Related Pathways

Others

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/unc2383.html

Purity

98.68

Solubility

DMSO : 20 mg/mL (ultrasonic)

Smiles

O=C(C(O1)=CC2=C1C=CC(Cl)=C2)NC3=NC4=CC=CC=C4N3CCN5CCCC5

Molecular Formula

C22H21ClN4O2

Molecular Weight

408.88

References & Citations

[1]Ling Wang, et al. A Novel Family of Small Molecules that Enhance the Intracellular Delivery and Pharmacological Effectiveness of Antisense and Splice Switching Oligonucleotides. ACS Chem Biol. 2017 Aug 18;12 (8) :1999-2007.|[2]Munson MJ, et al. A high-throughput Galectin-9 imaging assay for quantifying nanoparticle uptake, endosomal escape and functional RNA delivery. Commun Biol. 2021 Feb 16;4 (1) :211. |[3]Dang Y, et al. Enhanced delivery of peptide-morpholino oligonucleotides with a small molecule to correct splicing defects in the lung. Nucleic Acids Res. 2021 Jun 21;49 (11) :6100-6113.