UNC2383
UNC2383 is an oligonucleotide enhancer compound. UNC2383 can enhance the efficacy of antisense oligonucleotides (ASOs) and splice-switching oligonucleotides (SSOs) . UNC2383 can be used in research of diseases involving impaired oligonucleotide delivery, such as cystic fibrosis[1][2][3].
Product Specifications
CAS Number
2123481-48-9
UNSPSC
12352005
Target
Biochemical Assay Reagents
Type
Oligonucleotides
Related Pathways
Others
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/unc2383.html
Purity
98.68
Solubility
DMSO : 20 mg/mL (ultrasonic)
Smiles
O=C(C(O1)=CC2=C1C=CC(Cl)=C2)NC3=NC4=CC=CC=C4N3CCN5CCCC5
Molecular Formula
C22H21ClN4O2
Molecular Weight
408.88
References & Citations
[1]Ling Wang, et al. A Novel Family of Small Molecules that Enhance the Intracellular Delivery and Pharmacological Effectiveness of Antisense and Splice Switching Oligonucleotides. ACS Chem Biol. 2017 Aug 18;12 (8) :1999-2007.|[2]Munson MJ, et al. A high-throughput Galectin-9 imaging assay for quantifying nanoparticle uptake, endosomal escape and functional RNA delivery. Commun Biol. 2021 Feb 16;4 (1) :211. |[3]Dang Y, et al. Enhanced delivery of peptide-morpholino oligonucleotides with a small molecule to correct splicing defects in the lung. Nucleic Acids Res. 2021 Jun 21;49 (11) :6100-6113.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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