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(R) -GNE-140

(R) -GNE-140 is a potent lactate dehydrogenase A (LDHA) inhibitor, with IC50s of 3 nM and 5 nM for LDHA and LDHB, respectively; (R) -GNE-140 is 18-fold more potent than S enantiomer.

Product Specifications

CAS Number

2003234-63-5

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Lactate Dehydrogenase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/_R_-GNE-140.html

Concentration

10mM

Purity

99.77

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O=C1N[C@@](C2=CSC=C2)(C3=CC=C(N4CCOCC4)C=C3)CC(O)=C1SC5=CC=CC=C5Cl

Molecular Formula

C25H23ClN2O3S2

Molecular Weight

499.04

Precautions

H302, H315, H319, H335

References & Citations

[1]Purkey HE, et al. Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice. ACS Med Chem Lett. 2016 Aug 26;7 (10) :896-901.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

LDHA; LDHB

Available Sizes

Frequently Asked Questions

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