(R) -GNE-140
(R) -GNE-140 is a potent lactate dehydrogenase A (LDHA) inhibitor, with IC50s of 3 nM and 5 nM for LDHA and LDHB, respectively; (R) -GNE-140 is 18-fold more potent than S enantiomer.
Product Specifications
CAS Number
[2003234-63-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Lactate Dehydrogenase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/_R_-GNE-140.html
Concentration
10mM
Purity
99.77
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C1N[C@@](C2=CSC=C2)(C3=CC=C(N4CCOCC4)C=C3)CC(O)=C1SC5=CC=CC=C5Cl
Molecular Formula
C25H23ClN2O3S2
Molecular Weight
499.04
Precautions
H302, H315, H319, H335
References & Citations
[1]Purkey HE, et al. Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice. ACS Med Chem Lett. 2016 Aug 26;7 (10) :896-901.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
LDHA; LDHB
Available Sizes
Curated Selection
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