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Diethyl succinate (Standard)

Diethyl succinate (Standard) is the analytical standard of Diethyl succinate. This product is intended for research and analytical applications. Diethyl succinate (Diethyl Butanedioate) can be utilized at physiological pH, allowing it to penetrate biological membranes and integrate into the cells of tissue cultures, where it is metabolized via the tricarboxylic acid cycle. Diethyl succinate modulates the polarization and activation of microglial cells by reducing mitochondrial fission and the levels of reactive oxygen species (ROS), thereby exerting an inflammatory protective effect in primary microglial cells. Furthermore, Diethyl succinate is non-toxic and can be used in flavorings and seasonings[1][2].

Product Specifications

CAS Number

123-25-1

Product Name Alternative

Diethyl Butanedioate (Standard)

UNSPSC

12352211

Target

Biochemical Assay Reagents; Reactive Oxygen Species (ROS) ; Reference Standards

Type

Reference Standards

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/diethyl-succinate-standard.html

Smiles

O=C(OCC)CCC(OCC)=O

Molecular Formula

C8H14O4

Molecular Weight

174.19

References & Citations

[1]Zacharias NM, et al. Real-time molecular imaging of tricarboxylic acid cycle metabolism in vivo by hyperpolarized 1- (13) C diethyl succinate. J Am Chem Soc. 2012 Jan 18;134 (2) :934-43.|[2]Lixiang Wang, et al. "Diethyl succinate modulates microglial polarization and activation by reducing mitochondrial fission and cellular ROS." Metabolites 11.12 (2021) : 854.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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