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HDAC-IN-83

HDAC-IN-83 (compound 9D) is an inhibitor of deacetylases (HDACs) (IC50=0.01 μM/0.44 μM HDAC1/HDAC6) with anticancer, antiproliferative and caspase 3/7 activation activities. HDAC-IN-83 inhibits Cal27, HepG2 and MRC-5 with IC50s of 0.693 μM, 0.427 μM and 3.19 μM, respectively[1].

Product Specifications

UNSPSC

12352005

Target

HDAC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hdac-in-83.html

Smiles

O=C(C1=CN=C(N2CCC(CN(CC(NC3CCCCC3)=O)C(C4=CC=C(C(C)C)C=C4)=O)CC2)N=C1)NO

Molecular Formula

C29H40N6O4

Molecular Weight

536.67

References & Citations

[1]Stopper D, et al. Multicomponent syntheses enable the discovery of novel quisinostat-derived chemotypes as histone deacetylase inhibitors. Eur J Med Chem. 2025 Jan 5;281:117045.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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