IL-1R2, Cynomolgus (HEK293, Fc)

Product Specifications

UNSPSC Description

IL-1R2 is a competitive endogenous inhibitor of IL-1 signaling. IL-1R2 serves as a decoy receptor and competes with IL-1R1 for IL-1, it can also form a complex with IL-1RAP once it binds IL-1. IL-1R2 is implicated in various IL-1-mediated inflammatory diseases[1]. IL-1R2 Protein, Cynomolgus (HEK293, Fc) is a recombinant cynomolgus IL-1R2 protein with an hFc tag at the C-terminus and is expressed in HEK293 cells. It consists of 343 amino acids (M1-E343).

Type

Recombinant Proteins

Assay Protocol

https://www.medchemexpress.com/cytokines/il-1r2-protein-cynomolgus-hek293-fc.html

Purity

98.0

Smiles

FTLQPAAHT GAARSCRFRG RHYKREFRLE GEPVALRCPQ VPYRLWASVS PHINLTWHKN DSARMVPGEE ETRMWAQDGA LWLLPALQED SGTYICTTRN ASYCDKVSIE LRVFENTDAS LPFISYPQIL TLSTSGVLVC PDLREFTRDK TDVKIQWYKD SLPLDKDNEK FLSVRGTTHL LVHDVALEDA GYYRCVLTFA HEGQQYNITR TVELRIKKKK EETIPVIISP LKTISASLGS RLTIPCKVFL GTGTPLTTML WWTANDTHVE SAYPGGRVTE GPRQEYSENN ENYIEVPLIF DPVTREDLNM DFKCVVRNTL GFQTLRTTVK E

Molecular Weight

Approximately 80-95 kDa

References & Citations

[1]PetersVA,etal.IL-1receptor2(IL-1R2)anditsroleinimmuneregulation.BrainBehavImmun.2013Aug;32:1-8.|[2]Molgora M, et al. Tuning inflammation and immunity by the negative regulators IL-1R2 and IL-1R8. Immunol Rev. 2018 Jan;281(1):233-247.|[3]Lin J, et al. Cardiomyocyte IL-1R2 protects heart from ischemia/reperfusion injury by attenuating IL-17RA-mediated cardiomyocyte apoptosis. Cell Death Dis. 2022 Jan 27;13(1):90.