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IL-1R2, Cynomolgus (HEK293, Fc)

IL-1R2 is a competitive endogenous inhibitor of IL-1 signaling. IL-1R2 serves as a decoy receptor and competes with IL-1R1 for IL-1, it can also form a complex with IL-1RAP once it binds IL-1. IL-1R2 is implicated in various IL-1-mediated inflammatory diseases[1]. IL-1R2 Protein, Cynomolgus (HEK293, Fc) is a recombinant cynomolgus IL-1R2 protein with an hFc tag at the C-terminus and is expressed in HEK293 cells. It consists of 343 amino acids (M1-E343) .

Product Specifications

Product Name Alternative

IL-1R2 Protein, Cynomolgus (HEK293, Fc), Cynomolgus, HEK293

UNSPSC

12352202

Type

Recombinant Proteins

Assay Protocol

https://www.medchemexpress.com/cytokines/il-1r2-protein-cynomolgus-hek293-fc.html

Purity

98.0

Smiles

FTLQPAAHTGAARSCRFRGRHYKREFRLEGEPVALRCPQVPYRLWASVSPHINLTWHKNDSARMVPGEEETRMWAQDGALWLLPALQEDSGTYICTTRNASYCDKVSIELRVFENTDASLPFISYPQILTLSTSGVLVCPDLREFTRDKTDVKIQWYKDSLPLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRTVELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHVESAYPGGRVTEGPRQEYSENNENYIEVPLIFDPVTREDLNMDFKCVVRNTLGFQTLRTTVKE

Molecular Formula

711638 (Gene_ID) Q8HXR9 (F14-E343) (Accession)

Molecular Weight

Approximately 80-95 kDa

References & Citations

[1]PetersVA, etal.IL-1receptor2 (IL-1R2) anditsroleinimmuneregulation.BrainBehavImmun.2013Aug;32:1-8.|[2]Molgora M, et al. Tuning inflammation and immunity by the negative regulators IL-1R2 and IL-1R8. Immunol Rev. 2018 Jan;281 (1) :233-247.|[3]Lin J, et al. Cardiomyocyte IL-1R2 protects heart from ischemia/reperfusion injury by attenuating IL-17RA-mediated cardiomyocyte apoptosis. Cell Death Dis. 2022 Jan 27;13 (1) :90.

Shipping Conditions

Room temperature in continental US; may vary elsewhere.

Storage Conditions

Stored at -20°C for 2 years

Scientific Category

Recombinant Proteins

Available Sizes

Frequently Asked Questions

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