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Malic enzyme inhibitor ME1

Product Specifications

Product Name Alternative

ME1

UNSPSC Description

Malic enzyme inhibitor ME1 (ME1; compound 1) is a potent inhibitor of Malic enzyme (ME1) with an IC50 of 0.15 μM[1][2].

Target Antigen

Fatty Acid Synthase (FASN)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/malic-enzyme-inhibitor-me1.html

Purity

99.69

Solubility

DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C)

Smiles

O=C(C(N1CCN(C2=CC=C(O)C=C2)CC1)C3)N(C4=CC=CC=C4)C3=O

Molecular Weight

351.40

References & Citations

[1]Zhang YJ, et al. In silico design and synthesis of piperazine-1-pyrrolidine-2,5-dione scaffold-based novel malic enzyme inhibitors. Bioorg Med Chem Lett. 2006 Feb;16(3):525-8. Epub 2005 Nov 8.|[2]Fernandes L, et al. Malic Enzyme 1 (ME1) is pro-oncogenic in ApcMin/+ mice. Sci Rep. 2018 Sep 24;8(1):14268.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-124861/Malic-enzyme-inhibitor-ME1-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-124861/Malic-enzyme-inhibitor-ME1-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

522649-59-8

Available Sizes

Curated Selection

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