Flubendazole-d3

Flubendazole-d3 is the deuterium labeled Flubendazole. Flubendazole is a safe and efficacious anthelmintic agent, which is widely used for anthelmintic to human, rodents and ruminants. Flubendazole exerts anticancer activities by mechanisms including inhibition of microtubule function. Flubendazole induces p53-mediated apoptosis and arrests G2/M cell cycle[1][2].

Product Specifications

CAS Number

[1173021-08-3]

UNSPSC

12352005

Target

Apoptosis; Microtubule/Tubulin; Parasite

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

Field of Research

Cancer; Infection

Purity

96.00

Solubility

10 mM in DMSO|DMSO : 4.17mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C(F)C=C1)C2=CC=C(N=C(NC(OC([2H])([2H])[2H])=O)N3)C3=C2

Molecular Formula

C16H9D3FN3O3

Molecular Weight

316.30

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Michaelis M, et al. Identification of flubendazole as potential anti-neuroblastoma compound in a large cell line screen. Sci Rep. 2015 Feb 3;5:8202.|[3]Zhou X, et al. Flubendazole inhibits glioma proliferation by G2/M cell cycle arrest and pro-apoptosis. Cell Death Discov. 2018 Feb 14;4:18.