Flubendazole-d3
Product Specifications
UNSPSC Description
Flubendazole-d3 is the deuterium labeled Flubendazole. Flubendazole is a safe and efficacious anthelmintic agent, which is widely used for anthelmintic to human, rodents and ruminants. Flubendazole exerts anticancer activities by mechanisms including inhibition of microtubule function. Flubendazole induces p53-mediated apoptosis and arrests G2/M cell cycle[1][2].
Target Antigen
Apoptosis; Microtubule/Tubulin; Parasite
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection;Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton
Field of Research
Cancer; Infection
Purity
97.74
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C(F)C=C1)C2=CC=C(N=C(NC(OC([2H])([2H])[2H])=O)N3)C3=C2
Molecular Weight
316.30
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Michaelis M, et al. Identification of flubendazole as potential anti-neuroblastoma compound in a large cell line screen. Sci Rep. 2015 Feb 3;5:8202.|[3]Zhou X, et al. Flubendazole inhibits glioma proliferation by G2/M cell cycle arrest and pro-apoptosis. Cell Death Discov. 2018 Feb 14;4:18.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Clinical Information
No Development Reported
CAS Number
1173021-08-3
Available Sizes
Curated Selection
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