EBP-IN-1
EBP-IN-1 (compound 11) is an inhibitor of emopamil-binding protein (EBP), a sterol isomerase in the cholesterol biosynthetic pathway. EBP-IN-1 has a long half-life in rodents and has good metabolic turnover and brain penetration properties. EBP-IN-1 enhances oligodendrocyte formation in human cortical organoids[1].
Product Specifications
CAS Number
3034437-44-7
UNSPSC
12352005
Target
Emopamil Binding Protein
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ebp-in-1.html
Purity
99.77
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCN1C(N(C2=CC=C(C3CC3)C=C2)C(C14CCN(CC5CCOCC5)CC4)=O)=O
Molecular Formula
C24H33N3O3
Molecular Weight
411.54
References & Citations
[1]Dorel R, et al. Discovery and Optimization of Selective Brain-Penetrant EBP Inhibitors that Enhance Oligodendrocyte Formation. J Med Chem. 2024 Mar 12.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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