Tenovin-3
Tenovin-3 is a p53 activator[1][2].
Product Specifications
CAS Number
[1011301-27-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Ligands for Target Protein for PROTAC; MDM-2/p53; Sirtuin
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Tenovin-3.html
Concentration
10mM
Purity
98.0
Solubility
DMSO : ≥ 31 mg/mL
Smiles
O=C(NC(NC1=CC=C(N)C=C1)=S)C2=CC=C(C(C)(C)C)C=C2
Molecular Formula
C18H21N3OS
Molecular Weight
327.44
Precautions
H302, H315, H319, H335
References & Citations
[1]Lain S, et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008 May;13 (5) :454-63.|[2]Jifei Miao, et al. Nuclear HMGB1 promotes the phagocytic ability of macrophages. Exp Cell Res. 2020 Aug 1;393 (1) :112037.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT3
Available Sizes
Curated Selection
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