Tenovin-3

Tenovin-3 is a p53 activator[1][2].

Product Specifications

CAS Number

[1011301-27-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Ligands for Target Protein for PROTAC; MDM-2/p53; Sirtuin

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Tenovin-3.html

Concentration

10mM

Purity

98.0

Solubility

DMSO : ≥ 31 mg/mL

Smiles

O=C(NC(NC1=CC=C(N)C=C1)=S)C2=CC=C(C(C)(C)C)C=C2

Molecular Formula

C18H21N3OS

Molecular Weight

327.44

Precautions

H302, H315, H319, H335

References & Citations

[1]Lain S, et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008 May;13 (5) :454-63.|[2]Jifei Miao, et al. Nuclear HMGB1 promotes the phagocytic ability of macrophages. Exp Cell Res. 2020 Aug 1;393 (1) :112037.