GRK2 (Phospho-Tyr86) rabbit pAb
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008],
Product Specifications
Background
UniProt
P25098
Swiss Prot
P25098
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human GRK2 (Phospho-Tyr86)
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; WB
Concentration
1 mg/ml
Dilution
IHC-p 1:50-200, WB 1:500-2000
Molecular Weight
75kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
75kD
Fragment
IgG
Subcellular Location
Cytoplasm . Cell membrane . Cell junction, synapse, postsynapse . Cell junction, synapse, presynapse .
Other Product Names
Beta-adrenergic receptor kinase 1 (Beta-ARK-1; EC 2.7.11.15; G-protein coupled receptor kinase 2)
Gene ID (Human)
156
Available Sizes
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