Estradiol 17- (β-D-Glucuronide)

Estradiol 17- (β-D-Glucuronide), a metabolite of estrogen, is well known to cause intrahepatic cholestasis in humans. Estradiol 17- (β-D-Glucuronide) is a high-affinity substrate for oatp organic anion transporter[1].

Product Specifications

CAS Number

[1806-98-0]

UNSPSC

12352005

Hazard Statement

H302+H312+H332, H315, H319, H335

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/estradiol-17-β-d-glucuronide.html

Purity

99.0

Solubility

DMSO : 4.5 mg/mL (ultrasonic; warming)

Smiles

C[C@@]12[C@](CC[C@@H]2O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)C(O)=O)([H])[C@@]4([H])[C@@](CC1)([H])C5=CC=C(O)C=C5CC4

Molecular Formula

C24H32O8

Molecular Weight

448.51

Precautions

H302+H312+H332, H315, H319, H335

References & Citations

[1]Kinbara S, et al. Improvement of estradiol-17 beta-D-glucuronide-induced cholestasis by sodium tauroursodeoxycholate therapy in rats. Scand J Gastroenterol. 1997;32 (9) :947-952.|[2]Kanai N, et al. Estradiol 17 beta-D-glucuronide is a high-affinity substrate for oatp organic anion transporter. Am J Physiol. 1996 Feb;270 (2 Pt 2) :F326-31.