MB-07811

MB-07811 (VK-2809) is an orally active HepDirect prodrug of MB07344, a liver-targeted thyroid hormone receptor-β agonist[1]. MB-07811 has cholesterol and triglycerides lowering activity[2].

Product Specifications

CAS Number

[852948-13-1]

Product Name Alternative

VK-2809

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Thyroid Hormone Receptor

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/mb-07811.html

Purity

99.75

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

OC1=CC=C(CC2=C(C)C=C(OC[P@]3(OCC[C@@H](C4=CC=CC(Cl)=C4)O3)=O)C=C2C)C=C1C(C)C

Molecular Formula

C28H32ClO5P

Molecular Weight

514.98

Precautions

H302, H315, H319, H335

References & Citations

[1]Cable EE, et al. Reduction of hepatic steatosis in rats and mice after treatment with aliver-targeted thyroidhormone receptor agonist. Hepatology. 2009 Feb;49 (2) :407-17.|[2]Erion MD, et al. Targeting thyroid hormone receptor-beta agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index. Proc Natl Acad Sci U S A. 2007 Sep 25;104 (39) :15490-5.