BCN-PEG4-NHS ester

BCN-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. BCN-PEG4-NHS ester is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

Product Specifications

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

ADC Linker; PROTAC Linkers

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bcn-peg4-nhs-ester.html

Purity

95.0

Solubility

10 mM in DMSO

Smiles

[H][C@@]12[C@@](CCC#CCC2)([H])[C@@H]1COC(NCCOCCOCCOCCOCCC(ON3C(CCC3=O)=O)=O)=O

Molecular Formula

C26H38N2O10

Molecular Weight

538.59

Precautions

H302, H315, H319, H335

References & Citations

[1]"An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. "