Efflux inhibitor-1

Efflux inhibitor-1 (compound 2) is a pyrazolo[1,5-a]pyrimidine efflux inhibitor. Efflux inhibitor-1 selectively targets toward ABCG2/BCRP over ABCB1 with IC50s of 0.45 μM and 2.17 μM, respectively[1].

Product Specifications

CAS Number

[1776055-29-8]

UNSPSC

12352005

Target

BCRP

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/efflux-inhibitor-1.html

Purity

98.0

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

COC1=CC=CC=C1C2=NN(C(N3CCN(C(C4=COC=C4)=O)CC3)=CC(C5=CC=CC=C5)=N6)C6=C2

Molecular Formula

C28H25N5O3

Molecular Weight

479.53

References & Citations

[1]Larson, et al. Selective efflux inhibitors and related pharmaceutical compositions and methods of treatment: United States, US9056111[P]. 2015-06-16.