GNE0877

GNE0877 is a highly selective, orally active and brain-penetrant LRRK2 inhibitor with an IC50 of 3 nM and a Ki of 0.7 nM. GNE0877 can be used for the research of neuroscience[1].

Product Specifications

CAS Number

[1374828-69-9]

UNSPSC

12352005

Hazard Statement

H317, H319

Target

LRRK2

Type

Reference compound

Related Pathways

Autophagy

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/GNE0877.html

Purity

99.81

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

CC1=NN(C(C)(C)C#N)C=C1NC2=NC=C(C(F)(F)F)C(NC)=N2

Molecular Formula

C14H16F3N7

Molecular Weight

339.32

Precautions

H317, H319

References & Citations

[1]Estrada AA, et al. Discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. J Med Chem. 2014 Feb 13;57 (3) :921-36.