EN450
Product Specifications
UNSPSC Description
EN450 is a cysteine-reactive covalent molecular glue degrader targeting NF-κB. EN450 interacts with allosteric C111 in the E2 ubiquitin ligase UBE2D. EN450 induces the ternary complex formation between UBE2D and NFKB1. EN450 exerts its anti-proliferative effects through a Cullin E3 ligase and proteasome-dependent mechanism[1].
Target Antigen
E1/E2/E3 Enzyme; Molecular Glues; NF-κB
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease;NF-κB;PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/en450.html
Purity
99.28
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC(S(=O)(N(C)C)=O)=CC=C1Cl)C=C
Molecular Weight
288.756
References & Citations
[1]King EA, et al. Chemoproteomics-enabled discovery of a covalent molecular glue degrader targeting NF-κB. Cell Chem Biol. 2023 Apr 20;30(4):394-402.e9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-49444/EN450-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-49444/EN450-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
793719-01-4
Available Sizes
Curated Selection
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