QO 58
QO 58 is a potent modulator of K (v) 7 channels. QO-58 increases the current amplitudes, shifts the voltage-dependent activation curve in a more negative direction and slows the deactivation of K (v) 7.2/K (v) 7.3 currents. QO-58 has the potential for the research of diseases associated with neuronal hyperexcitability[1].
Product Specifications
CAS Number
1259536-62-3
UNSPSC
12352005
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/qo-58.html
Purity
99.01
Solubility
DMSO : ≥ 62.5 mg/mL
Smiles
O=C1C=C(C2=C(Cl)N=C(Cl)C(F)=C2)NC3=C(C(C(F)(F)F)=NN13)C4=CC=CC=C4
Molecular Formula
C18H8Cl2F4N4O
Molecular Weight
443.18
References & Citations
[1]Zhang F, et al. Modulation of K (v) 7 potassium channels by a novel opener pyrazolo[1,5-a]pyrimidin-7 (4H) -one compound QO-58. Br J Pharmacol. 2013;168 (4) :1030-1042.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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