Vialinin A

Vialinin A (Terrestrin A) is a p-terphenyl compound that can be derived from a Chinese edible mushroom. Vialinin A is an inhibitor of ubiquitin-specific peptidase 4 (USP4) and has anti-inflammatory and antioxidant properties. Vialinin A can alleviate cerebral ischaemia-reperfusion injury-induced neurological deficits and neuronal apoptosis. Vialinin A promotes activation of Keap1-Nrf2-ARE signaling pathway and increases the protein degradation of Keap1. Vialinin A possesses various pharmacological activities in cancer, Kawasaki disease, asthma, and pathological scarring. Vialinin A is a potent inhibitor of TNF-α, USP4, USP5, and sentrin/SUMO-specific protease 1 (SENP1) . Vialinin A can be studied in reseach for autoimmune diseases, cancer and ischaemic stroke[1][2][3].

Product Specifications

CAS Number

[858134-23-3]

Product Name Alternative

Terrestrin A

UNSPSC

12352005

Target

Deubiquitinase; E1/E2/E3 Enzyme; Keap1-Nrf2; TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-anti-virus

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/vialinin-a.html

Purity

99.90

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(CC1=CC=CC=C1)OC2=C(C(C3=CC=C(C=C3)O)=C(C(O)=C2C4=CC=C(O)C=C4)O)OC(CC5=CC=CC=C5)=O

Molecular Formula

C34H26O8

Molecular Weight

562.57

References & Citations

[1]Ji-Kai Liu, et al. Natural terphenyls: developments since 1877. Chem Rev. 2006 Jun;106 (6) :2209-23.|[2]Jie Xu, et al. Ubiquitously specific protease 4 inhibitor-Vialinin A attenuates inflammation and fibrosis in S100-induced hepatitis mice through Rheb/mTOR signalling.J Cell Mol Med. 2021 Jan;25 (2) :1140-1150. |[3]Himangshu Sonowal, et al. Vialinin A, an Edible Mushroom-Derived p-Terphenyl Antioxidant, Prevents VEGF-Induced Neovascularization In Vitro and In Vivo. Oxid Med Cell Longev. 2018 Feb 6;2018:1052102.