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EGFR/HER2-IN-9

EGFR/HER2-IN-9 (Compound 1) is an EGFR and HER2 inhibitor with IC50s of 3.2, 8.3 and 14 nM against EGFR, EGFR T790M and HER2, respectively[1].

Product Specifications

CAS Number

1637253-79-2

UNSPSC

12352005

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/egfr-her2-in-9.html

Purity

98.73

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC(C(NC(/C=C/CN1C[C@@]2([H])[C@@](OCCO2)([H])C1)=O)=C3)=CC4=C3C(NC5=CC(Cl)=C(C=C5)F)=NC=N4

Molecular Formula

C25H25ClFN5O4

Molecular Weight

513.95

References & Citations

[1]Yingjun Zhang, et al. Amino quinazoline derivatives as well as salts and application method thereof. Patent CN104119350A.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

EGFR/ErbB1/HER1; ErbB2/HER2

Available Sizes

Frequently Asked Questions

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