Amino-PEG8-Boc
Amino-PEG8-Boc is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Amino-PEG8-Boc is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Product Specifications
CAS Number
[756526-06-4]
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/amino-peg8-boc.html
Purity
99.85
Solubility
10 mM in DMSO
Smiles
NCCOCCOCCOCCOCCOCCOCCOCCOCCC(OC(C)(C)C)=O
Molecular Formula
C23H47NO10
Molecular Weight
497.62
Precautions
H302, H315, H319, H335
References & Citations
[1]Hans-Georg Lerchen, et al. Antibody drug conjugates (adcs) and antibody prodrug conjugates (apdcs) with enzymatically cleavable groups. WO2016207089A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Alkyl/ether Linkers; Cleavable Linker; PEG Linkers
Available Sizes
Curated Selection
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