Fumonisin B1-13C34

Fumonisin B1-13C34 is the 13C labeled Fumonisin B1 (HY-N6719) [1]. Fumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin[2][3].

Product Specifications

CAS Number

[1217458-62-2]

UNSPSC

12352211

Hazard Statement

H225-H302+H312+H332-H319

Target

Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/fumonisin-b1-13c34.html

Concentration

33.08 μM * 1.2 mL in Acetonitrile

Solubility

10 mM in DMSO

Smiles

O[13C]([13CH2][13C@@H]([13C](O)=O)[13CH2][13C](O[13C@@H]([13CH2][13C@@H]([13CH3])[13CH2][13C@H](O)[13CH2][13CH2][13CH2][13CH2][13C@@H](O)[13CH2][13C@H](O)[13C@@H](N)[13CH3])[13C@@H]([13C@H]([13CH3])[13CH2][13CH2][13CH2][13CH3])O[13C]([13CH2][13C@H]([13C](O)=O)[13CH2][13C](O)=O)=O)=O)=O

Molecular Formula

13C34H59NO15

Molecular Weight

755.58

Precautions

P210-P233-P240-P241-P242-P243-P261-P264-P270-P271-P280-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P330-P362+P364-P370+P378-P403+P235-P501

References & Citations

[1]Henry MH, et al. The toxicity of fumonisin B1, B2, and B3, individually and in combination, in chicken embryos. Poult Sci. 2001 Apr;80 (4) :401-7.|[2]Wang SK, et al. Effect of fumonisin B₁ on the cell cycle of normal human liver cells. Mol Med Rep. 2013 Jun;7 (6) :1970-6.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-220.