Doxorubicinol (hydrochloride)

Doxorubicinol hydrochloride (13-Dihydroadriamycin hydrochloride) is a secondary alcohol metabolite of Doxorubicin[1].

Product Specifications

CAS Number

[63950-05-0]

Product Name Alternative

13-Dihydroadriamycin (hydrochloride)

UNSPSC

12352005

Target

Drug Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/doxorubicinol-hydrochloride.html

Purity

99.0

Solubility

10 mM in DMSO

Smiles

OC1=C(C[C@]([C@@H](O)CO)(O)C[C@@H]2O[C@@](O[C@@H](C)[C@H]3O)([H])C[C@@H]3N)C2=C(O)C(C4=O)=C1C(C5=CC=CC(OC)=C45)=O.Cl[H]

Molecular Formula

C27H32ClNO11

Molecular Weight

582.00

References & Citations

[1]Kamil Piska, et al. Metabolic carbonyl reduction of anthracyclines - role in cardiotoxicity and cancer resistance. Reducing enzymes as putative targets for novel cardioprotective and chemosensitizing agents. Invest New Drugs. 2017 Jun;35 (3) :375-385.|[2]J van Asperen, et al. Increased accumulation of doxorubicin and doxorubicinol in cardiac tissue of mice lacking mdr1a P-glycoprotein. Br J Cancer. 1999 Jan;79 (1) :108-13.