Cardamonin

Cardamonin can be found from cardamom, and can target various signaling molecules, transcriptional factors, cytokines and enzymes. Cardamonin can inhibit mTOR, NF-κB, Akt, STAT3, Wnt/β-catenin and COX-2. Cardamonin shows anticancer, anti-inflammatory, antimicrobial and antidiabetic activities[1][2].

Product Specifications

CAS Number

[18956-16-6]

Product Name Alternative

Cardamomin; Alpinetin chalcone

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Bcl-2 Family; NF-κB; STAT; Wnt; β-catenin

Type

Natural Products

Related Pathways

Apoptosis; JAK/STAT Signaling; NF-κB; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/cardamonin-1.html

Purity

98.38

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(C1=C(OC)C=C(O)C=C1O)/C=C/C2=CC=CC=C2

Molecular Formula

C16H14O4

Molecular Weight

270.28

Precautions

H302, H315, H319, H335

References & Citations

[1]Javaria Nawaz, et al. Cardamonin: A new player to fight cancer via multiple cancer signaling pathways. Life Sci. 2020 Jun 1;250:117591.|[2]Kai Wang, et al. Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway. Biochem Pharmacol. 2018 Sep;155:494-509.|[3]Zheng Wang, et al. Cardamonin exerts anti-gastric cancer activity via inhibiting LncRNA-PVT1-STAT3 axis. Biosci Rep. 2019 May 17;39 (5) :BSR20190357.|[4]Wang Qi, et al. Cardamonin protects against doxorubicin-induced cardiotoxicity in mice by restraining oxidative stress and inflammation associated with Nrf2 signaling. Biomed Pharmacother. 2020 Feb;122:109547.