Cardamonin
Product Specifications
UNSPSC Description
Cardamonin can be found from cardamom, and target various signaling molecules, transcriptional factors, cytokines and enzymes. Cardamonin can inhibit mTOR, NF-κB, Akt, STAT3, Wnt/β-catenin and COX-2. Cardamonin shows anticancer, anti-inflammatory, antimicrobial and antidiabetic activities[1][2].
Target Antigen
Apoptosis; Bcl-2 Family; NF-κB; STAT; Wnt; β-catenin
Type
Natural Products
Related Pathways
Apoptosis;JAK/STAT Signaling;NF-κB;Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/cardamonin-1.html
Purity
98.38
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C1=C(OC)C=C(O)C=C1O)/C=C/C2=CC=CC=C2
Molecular Weight
270.28
References & Citations
[1]Javaria Nawaz, et al. Cardamonin: A new player to fight cancer via multiple cancer signaling pathways. Life Sci. 2020 Jun 1;250:117591.|[2]Kai Wang, et al. Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway. Biochem Pharmacol. 2018 Sep;155:494-509.|[3]Zheng Wang, et al. Cardamonin exerts anti-gastric cancer activity via inhibiting LncRNA-PVT1-STAT3 axis. Biosci Rep. 2019 May 17;39(5):BSR20190357.|[4]Wang Qi, et al. Cardamonin protects against doxorubicin-induced cardiotoxicity in mice by restraining oxidative stress and inflammation associated with Nrf2 signaling. Biomed Pharmacother. 2020 Feb;122:109547.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N0279/Cardamonin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N0279/Cardamonin-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
18956-16-6
Available Sizes
Curated Selection
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