Allethrin

Allethrin, a pyrethroid insecticide is a major mosquito repellent agent. Allethrin induces oxidative stress, apoptosis and calcium release in rat testicular carcinoma cells (LC540) . Allethrin induces BCL-2, caspase-3 activation and release of intracellular calcium[1].

Product Specifications

CAS Number

[584-79-2]

UNSPSC

12352211

Hazard Statement

H302+H332, H410

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/allethrin.html

Purity

98.04

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1C(C)(C)C1/C=C(C)\C)OC2C(C)=C(CC=C)C(C2)=O

Molecular Formula

C19H26O3

Molecular Weight

302.41

Precautions

H302+H332, H410

References & Citations

[1]Golla Madhubabu, et al. Allethrin induces oxidative stress, apoptosis and calcium release in rat testicular carcinoma cells (LC540) . Toxicol In Vitro. 2014 Dec;28 (8) :1386-95.|[2]Geetika Gupta, et al. Allethrin toxicity on human corneal epithelial cells involves mitochondrial pathway mediated apoptosis. Toxicol In Vitro. 2013 Dec;27 (8) :2242-8.|[3]Golla Madhubabu, et al. Allethrin induced toxicity in the male reproductive tract of rats contributes to disruption in the transcription of genes involved in germ cell production. Environ Toxicol. 2014 Nov;29 (11) :1330-45.