Perzinfotel

Perzinfotel (EAA-090) is a potent, selective, and competitive NMDA receptor antagonist with neuroprotective effects. Perzinfotel (EAA-090) shows high affinity (IC50=30 nM) for the glutamate site[1][2].

Product Specifications

CAS Number

[144912-63-0]

Product Name Alternative

EAA-090

UNSPSC

12352005

Hazard Statement

H300

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/perzinfotel.html

Purity

99.43

Solubility

DMSO : 20.83 mg/mL (ultrasonic) |H2O : 5.88 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=C2NCCCN1CCP(O)(O)=O)C2=O

Molecular Formula

C9H13N2O5P

Molecular Weight

260.18

Precautions

H300

References & Citations

[1]Brandt MR, et al. Effects of the N-methyl-D-aspartate receptor antagonist perzinfotel [EAA-090; [2- (8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1 (7) -en-2-yl) -ethyl]phosphonic acid] on chemically induced thermal hypersensitivity. J Pharmacol Exp Ther. 2005 Jun;313 (3) :1379-86.|[2]Kinney WA, et al. Design and synthesis of [2- (8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1 (7) -en-2-yl) -ethyl]phosphonic acid (EAA-090), a potent N-methyl-D-aspartate antagonist, via the use of 3-cyclobutene-1,2-dione as an achiral alpha-amino acid bioisostere. J Med Chem. 1998 Jan 15;41 (2) :236-46.