Perzinfotel
Perzinfotel (EAA-090) is a potent, selective, and competitive NMDA receptor antagonist with neuroprotective effects. Perzinfotel (EAA-090) shows high affinity (IC50=30 nM) for the glutamate site[1][2].
Product Specifications
CAS Number
[144912-63-0]
Product Name Alternative
EAA-090
UNSPSC
12352005
Hazard Statement
H300
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/perzinfotel.html
Purity
99.43
Solubility
DMSO : 20.83 mg/mL (ultrasonic) |H2O : 5.88 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=C2NCCCN1CCP(O)(O)=O)C2=O
Molecular Formula
C9H13N2O5P
Molecular Weight
260.18
Precautions
H300
References & Citations
[1]Brandt MR, et al. Effects of the N-methyl-D-aspartate receptor antagonist perzinfotel [EAA-090; [2- (8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1 (7) -en-2-yl) -ethyl]phosphonic acid] on chemically induced thermal hypersensitivity. J Pharmacol Exp Ther. 2005 Jun;313 (3) :1379-86.|[2]Kinney WA, et al. Design and synthesis of [2- (8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1 (7) -en-2-yl) -ethyl]phosphonic acid (EAA-090), a potent N-methyl-D-aspartate antagonist, via the use of 3-cyclobutene-1,2-dione as an achiral alpha-amino acid bioisostere. J Med Chem. 1998 Jan 15;41 (2) :236-46.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
NMDA Receptor
Available Sizes
Curated Selection
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