Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Pranlukast-d4

Pranlukast-d4 is deuterium labeled Pranlukast. Pranlukast is a highly potent, selective and competitive antagonist of peptide leukotrienes. Pranlukast inhibits [3H]LTE4, [3H]LTD4, and [3H]LTC4 bindings to lung membranes with Kis of 0.63±0.11, 0.99±0.19, and 5640±680 nM, respectively.

Product Specifications

CAS Number

2713172-43-9

Product Name Alternative

ONO-1078-d4

UNSPSC

12352005

Hazard Statement

H315-H319

Target

Endogenous Metabolite; Isotope-Labeled Compounds; Leukotriene Receptor

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Solubility

10 mM in DMSO

Smiles

O=C1C=C(C2=NN=NN2)OC3=C1C=CC=C3NC(C4=C([2H])C([2H])=C(C([2H])=C4[2H])OCCCCC5=CC=CC=C5)=O

Molecular Formula

C27H19D4N5O4

Molecular Weight

485.53

Precautions

P264-P280-P302+P352-P305+P351+P338-P362+P364

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Fang SH, et al. Nuclear translocation of cysteinyl leukotriene receptor 1 is involved in oxygen-glucose deprivation-induced damage to endothelial cells. Acta Pharmacol Sin. 2012 Dec;33 (12) :1511-7.|[3]Obata T, et al. In vitro antagonism of ONO-1078, a newly developed anti-asthma agent, against peptide leukotrienes in isolated guinea pig tissues. Jpn J Pharmacol. 1992 Nov;60 (3) :227-37.|[4]Ogata M, et al. Protective effects of a leukotriene inhibitor and a leukotriene antagonist on endotoxin-induced mortality in carrageenan-pretreated mice. Infect Immun. 1992 Jun;60 (6) :2432-7.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Human EGLN3 Protein Lysate 20ug
IHUEGLN3PLLY20UG 20 µg

Human EGLN3 Protein Lysate 20ug

Sign In for Pricing
View Details
Tert-Butyl 7-azabicyclo[2.2.1]heptane-7-carboxylate
OR1063352-01 50 mg

Tert-Butyl 7-azabicyclo[2.2.1]heptane-7-carboxylate

Sign In for Pricing
View Details
Tert-Butyl 7-azabicyclo[2.2.1]heptane-7-carboxylate
OR1063352-02 100 mg

Tert-Butyl 7-azabicyclo[2.2.1]heptane-7-carboxylate

Sign In for Pricing
View Details
Tert-Butyl 7-azabicyclo[2.2.1]heptane-7-carboxylate
OR1063352-03 250 mg

Tert-Butyl 7-azabicyclo[2.2.1]heptane-7-carboxylate

Sign In for Pricing
View Details
Mouse Resistin ELISA Kit
BEK1197 96 Tests

Mouse Resistin ELISA Kit

Sign In for Pricing
View Details
AMZ2 Polyclonal Antibody
E-AB-10824-01 20 µL

AMZ2 Polyclonal Antibody

Sign In for Pricing
View Details