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Pranlukast-d4

Pranlukast-d4 is deuterium labeled Pranlukast. Pranlukast is a highly potent, selective and competitive antagonist of peptide leukotrienes. Pranlukast inhibits [3H]LTE4, [3H]LTD4, and [3H]LTC4 bindings to lung membranes with Kis of 0.63±0.11, 0.99±0.19, and 5640±680 nM, respectively.

Product Specifications

CAS Number

2713172-43-9

Product Name Alternative

ONO-1078-d4

UNSPSC

12352005

Hazard Statement

H315-H319

Target

Endogenous Metabolite; Isotope-Labeled Compounds; Leukotriene Receptor

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Solubility

10 mM in DMSO

Smiles

O=C1C=C(C2=NN=NN2)OC3=C1C=CC=C3NC(C4=C([2H])C([2H])=C(C([2H])=C4[2H])OCCCCC5=CC=CC=C5)=O

Molecular Formula

C27H19D4N5O4

Molecular Weight

485.53

Precautions

P264-P280-P302+P352-P305+P351+P338-P362+P364

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Fang SH, et al. Nuclear translocation of cysteinyl leukotriene receptor 1 is involved in oxygen-glucose deprivation-induced damage to endothelial cells. Acta Pharmacol Sin. 2012 Dec;33 (12) :1511-7.|[3]Obata T, et al. In vitro antagonism of ONO-1078, a newly developed anti-asthma agent, against peptide leukotrienes in isolated guinea pig tissues. Jpn J Pharmacol. 1992 Nov;60 (3) :227-37.|[4]Ogata M, et al. Protective effects of a leukotriene inhibitor and a leukotriene antagonist on endotoxin-induced mortality in carrageenan-pretreated mice. Infect Immun. 1992 Jun;60 (6) :2432-7.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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