Cipargamin
Cipargamin (NITD609) is an potent antimalarial compound, with an IC50 of appr 1 nM against P. falciparum.
Product Specifications
CAS Number
1193314-23-6
Product Name Alternative
NITD609; KAE609
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/NITD609.html
Purity
99.90
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
FC1=C(Cl)C=C(NC2=C3C[C@H](C)N[C@@]2(C4=C(C=CC(Cl)=C4)N5)C5=O)C3=C1
Molecular Formula
C19H14Cl2FN3O
Molecular Weight
390.24
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhou Y, et al. Spiroindolone that inhibits PfATPase4 is a potent, cidal inhibitor of Toxoplasma gondii tachyzoites in vitro and in vivo. Antimicrob Agents Chemother. 2014;58 (3) :1789-92.|[2]van Pelt-Koops JC, et al. The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks Plasmodium falciparum transmission to anopheles mosquito vector. Antimicrob Agents Chemother. 2012 Jul;56 (7) :3544-8.|[3]Rottmann M, et al. Spiroindolones, a potent compound class for the treatment of malaria. Science. 2010 Sep 3;329 (5996) :1175-80.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Plasmodium
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
K0237702 1.0 µg DNA
C4orf41 sgRNA CRISPR Lentivector (Human) (Target 1)
Sign In for Pricing
View Details 
MBS258451-01 25 Tests
Dual Poly Caspase and Mitochondrial Membrane Potential Assay Kit
Sign In for Pricing
View Details