Entecavir (monohydrate)
Entecavir monohydrate (BMS200475 monohydrate; SQ34676 monohydrate) is a potent and selective inhibitor of HBV, with an EC50 of 3.75 nM in HepG2 cell.
Product Specifications
CAS Number
209216-23-9
Product Name Alternative
BMS200475 (monohydrate) ; SQ34676 (monohydrate)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H332, H335
Target
HBV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/Entecavir-monohydrate.html
Purity
99.95
Solubility
DMSO : ≥ 50 mg/mL|H2O : 2.8 mg/mL (ultrasonic; warming)
Smiles
NC(N1)=NC(C2=C1N([C@@H](C[C@H](O)[C@H]3CO)C3=C)C=N2)=O.O
Molecular Formula
C12H17N5O4
Molecular Weight
295.29
Precautions
H302, H315, H319, H332, H335
References & Citations
[1]Innaimo SF, et al. Identification of?BMS-200475?as a potent and selective inhibitor of hepatitis B virus. Antimicrob Agents Chemother. 1997 Jul;41 (7) :1444-8.|[2]Rivkin A, et al. A review of entecavir in the treatment of chronic hepatitis B infection. Curr Med Res Opin.?2005 Nov;21 (11) :1845-56.|[3]Genovesi EV, et al. Efficacy of the carbocyclic 2'-deoxyguanosine nucleoside?BMS-200475?in the woodchuck model of hepatitis B virus infection. Antimicrob Agents Chemother.?1998 Dec;42 (12) :3209-17.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
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