Entecavir (monohydrate)

Entecavir monohydrate (BMS200475 monohydrate; SQ34676 monohydrate) is a potent and selective inhibitor of HBV, with an EC50 of 3.75 nM in HepG2 cell.

Product Specifications

CAS Number

[209216-23-9]

Product Name Alternative

BMS200475 (monohydrate) ; SQ34676 (monohydrate)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H332, H335

Target

HBV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/Entecavir-monohydrate.html

Purity

99.95

Solubility

DMSO : ≥ 50 mg/mL|H2O : 2.8 mg/mL (ultrasonic; warming)

Smiles

NC(N1)=NC(C2=C1N([C@@H](C[C@H](O)[C@H]3CO)C3=C)C=N2)=O.O

Molecular Formula

C12H17N5O4

Molecular Weight

295.29

Precautions

H302, H315, H319, H332, H335

References & Citations

[1]Innaimo SF, et al. Identification of?BMS-200475?as a potent and selective inhibitor of hepatitis B virus. Antimicrob Agents Chemother. 1997 Jul;41 (7) :1444-8.|[2]Rivkin A, et al. A review of entecavir in the treatment of chronic hepatitis B infection. Curr Med Res Opin.?2005 Nov;21 (11) :1845-56.|[3]Genovesi EV, et al. Efficacy of the carbocyclic 2'-deoxyguanosine nucleoside?BMS-200475?in the woodchuck model of hepatitis B virus infection. Antimicrob Agents Chemother.?1998 Dec;42 (12) :3209-17.