RETRA
RETRA is a mutant p53-dependent activator of p73 that suppresses mutant p53-bearing cancer cells. RETRA increases the expression level of p73, and a release of p73 from the blocking complex with mutant p53, which produces tumor-suppressor effects[1].
Product Specifications
CAS Number
1036069-26-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/retra.html
Purity
99.42
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
OC1=CC=C(C(CSC2=NCCS2)=O)C=C1O
Molecular Formula
C11H11NO3S2
Molecular Weight
269.34
Precautions
H302, H315, H319
References & Citations
[1]J E Kravchenko, et al. Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway. Proc Natl Acad Sci U S A. 2008 Apr 29;105 (17) :6302-7.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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