RETRA

RETRA is a mutant p53-dependent activator of p73 that suppresses mutant p53-bearing cancer cells. RETRA increases the expression level of p73, and a release of p73 from the blocking complex with mutant p53, which produces tumor-suppressor effects[1].

Product Specifications

CAS Number

[1036069-26-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

MDM-2/p53

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/retra.html

Purity

99.42

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

OC1=CC=C(C(CSC2=NCCS2)=O)C=C1O

Molecular Formula

C11H11NO3S2

Molecular Weight

269.34

Precautions

H302, H315, H319

References & Citations

[1]J E Kravchenko, et al. Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway. Proc Natl Acad Sci U S A. 2008 Apr 29;105 (17) :6302-7.