Donepezil (Hydrochloride)

Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE[1]. Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity[2].

Product Specifications

CAS Number

[120011-70-3]

Product Name Alternative

E2020

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Donepezil-Hydrochloride.html

Concentration

10mM

Purity

99.92

Solubility

DMSO : 6.2 mg/mL (warming) |H2O : 25 mg/mL (ultrasonic)

Smiles

O=C1C(CC2CCN(CC3=CC=CC=C3)CC2)CC4=C1C=C(OC)C(OC)=C4.[H]Cl

Molecular Formula

C24H30ClNO3

Molecular Weight

415.95

Precautions

H302, H315, H319, H335

References & Citations

[1]H Ogura, et al. Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find Exp Clin Pharmacol. 2000 Oct;22 (8) :609-13.|[2]Min-Young Noh, et al. Neuroprotective effects of donepezil through inhibition of GSK-3 activity in amyloid-beta-induced neuronal cell death. J Neurochem. 2009 Mar;108 (5) :1116-25.|[3]Chang Yell Shin, et al. The Effects of Donepezil, an Acetylcholinesterase Inhibitor, on Impaired Learning and Memory in Rodents. Biomol Ther (Seoul) . 2018 May 1;26 (3) :274-281.