GABAA receptor modulator-5
GABAA receptor modulator-5 (Compound S28) is a modulator for (γ-aminobutyric acid) A receptor (GABAA receptor), with EC50 of 56 nM and 10 nM, for α1β2γ2 and α4β3δ subtype. GABAA receptor modulator-5 exhibits good pharmacokinetic characteristics in rats. GABAA receptor modulator-5 is slightly toxic toxicity in rats with a loss of rollover reflex (LORR) threshold dose of 23.3 μmol/kg, and exhibits potential ameliorating the postpartum depression[1].
Product Specifications
CAS Number
3021554-08-2
UNSPSC
12352005
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gabaa-receptor-modular-3.html
Smiles
C[C@@]12[C@](CC[C@@H]2C(CN3C=NN(C4=CC(F)=NC(F)=C4)C3=O)=O)([H])[C@]5([H])CC[C@]6([H])C[C@@](O)(C)CC[C@]6([H])[C@@]5([H])CC1
Molecular Formula
C28H36F2N4O3
Molecular Weight
514.61
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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