Bis (maltolato) oxovanadium (IV)

Bis (maltolato) oxovanadium (IV) (BMOV) is a potent, reversible, competitive and orally active pan-PTP (protein tyrosine phosphatases) inhibitor. Bis (maltolato) oxovanadium (IV) inhibits HCPTPA, PTP1B, HPTPβ and SHP2 with IC50s of 126 nM, 109 nM, 26 nM and 201 nM, respectively. Bis (maltolato) oxovanadium (IV) is a potent insulin sensitizer[1][2].

Product Specifications

CAS Number

[38213-69-3]

Product Name Alternative

BMOV

UNSPSC

12352211

Hazard Statement

H301

Target

Phosphatase; SHP2

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/bis-maltolato-oxovanadium-iv.html

Purity

99.89

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=[V+2]([O-]C1=C2C)([O]=C1C=CO2)([O]=C3C=CO4)[O-]C3=C4C

Molecular Formula

C12H10O7V

Molecular Weight

317.15

Precautions

H301

References & Citations

[1] Janine Krüger, et al. Inhibition of Src homology 2 domain-containing phosphatase 1 increases insulin sensitivity in high-fat diet-induced insulin-resistant mice. FEBS Open Bio. 2016 Jan 4;6 (3) :179-89.|[2]Kevin G Peters, et al. Mechanism of insulin sensitization by BMOV (bis maltolato oxo vanadium) ; unliganded vanadium (VO4) as the active component. J Inorg Biochem. 2003 Aug 1;96 (2-3) :321-30.