Roemerine

Roemerine is an alkaloid that has been identified from the leaves of Fibraurea recisa Pierre. Roemerine exhibits antibacterial, anticancer, and antidepressant activities, can reverse the multidrug resistance phenotype in cultured cells, and exerts antibacterial effects by regulating the cAMP signaling pathway. Additionally, Roemerine influences neuronal activity by increasing BDNF protein expression and modulating the serotonergic and glutamatergic systems. Roemerine holds promise for research in the fields of cancer, infections, and neurological diseases[1][2][3][4][5].

Product Specifications

CAS Number

[548-08-3]

Product Name Alternative

(-) -Roemerine

UNSPSC

12352005

Target

5-HT Receptor; Antibiotic; Bacterial; Endogenous Metabolite; iGluR; mGluR

Type

Natural Products

Related Pathways

Anti-infection; GPCR/G Protein; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/roemerine.html

Purity

99.89

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CN1CCC(C2=C3C4=CC=CC=C4C[C@@]12[H])=CC5=C3OCO5

Molecular Formula

C18H17NO2

Molecular Weight

279.33

References & Citations

[1]M You, et al. (-) -Roemerine, an Aporphine Alkaloid From Annona Senegalensis That Reverses the Multidrug-Resistance Phenotype With Cultured Cells. J Nat Prod. 1995 Apr;58 (4) :598-604.|[2]Xu J, et al. Inhibition of proliferation, migration and invasion of RM-1 cells by roemerine: Insights from in vitro and in vivo studies. Tissue Cell. 2024 Dec 20;93:102693.|[3]Ma C, et al. Potent Activities of Roemerine against Candida albicans and the Underlying Mechanisms. Molecules. 2015 Sep 29;20 (10) :17913-28.|[4]Bayazeid O, et al. Neuroactivity of the naturally occurring aporphine alkaloid, roemerine. Nat Prod Res. 2021 Dec;35 (24) :6147-6152.|[5]Yin S, et al. Roemerine Improves the Survival Rate of Septicemic BALB/c Mice by Increasing the Cell Membrane Permeability of Staphylococcus aureus. PLoS One. 2015 Nov 25;10 (11) :e0143863.