17-ODYA

17-ODYA is a CYP450 ω-hydroxylase inhibitor. 17-ODYA is also a potent inhibitor (IC50[1][2][3]. 17-ODYA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[34450-18-5]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Cytochrome P450

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/17-odya.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C#CCCCCCCCCCCCCCCCC(O)=O

Molecular Formula

C18H32O2

Molecular Weight

280.45

Precautions

H302, H315, H319, H335

References & Citations

[1]Jiang S, et al. β-adrenergic Receptor-stimulated Cardiac Myocyte Apoptosis: Role of Cytochrome P450 ω-hydroxylase. J Cardiovasc Pharmacol. 2017;70 (2) :94-101. |[2]Zou AP, et al. Effects of 17-octadecynoic acid, a suicide-substrate inhibitor of cytochrome P450 fatty acid omega-hydroxylase, on renal function in rats. J Pharmacol Exp Ther. 1994;268 (1) :474-481.|[3]Nithipatikom K, et al. Inhibition of cytochrome P450omega-hydroxylase: a novel endogenous cardioprotective pathway. Circ Res. 2004;95 (8) :e65-e71.