Cyclin K degrader 1
Product Specifications
UNSPSC Description
Cyclin K degrader 1 (compound 40) is an AT7519 (HY-50940) based Cyclin K degrader with DC50 of 21 nM[1].
Target Antigen
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cyclin-k-degrader-1.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=NNC=C1NC(C2=C(Cl)C=CC=C2Cl)=O)NCC3=CC=C(C=C3)C4=CC=CC=N4
Molecular Weight
466.32
References & Citations
[1]Thomas KL, et al., Degradation by Design: New Cyclin K Degraders from Old CDK Inhibitors. ACS Chem Biol. 2024 Jan 19;19(1):173-184. doi: 10.1021/acschembio.3c00616
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-161168/Cyclin-K-degrader-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-161168/Cyclin-K-degrader-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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