Cyclin K degrader 1
Cyclin K degrader 1 (compound 40) is an AT7519 (HY-50940) based Cyclin K degrader with DC50 of 21 nM. Cyclin K degrader 1 has an affinity for cyclin K that is ~500-fold higher than its affinity for CDK12[1].
Product Specifications
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cyclin-k-degrader-1.html
Purity
99.86
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=NNC=C1NC(C2=C(Cl)C=CC=C2Cl)=O)NCC3=CC=C(C=C3)C4=CC=CC=N4
Molecular Formula
C23H17Cl2N5O2
Molecular Weight
466.32
References & Citations
[1]Thomas KL, et al., Degradation by Design: New Cyclin K Degraders from Old CDK Inhibitors. ACS Chem Biol. 2024 Jan 19;19 (1) :173-184. doi: 10.1021/acschembio.3c00616
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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