Cyclin K degrader 1

Cyclin K degrader 1 (compound 40) is an AT7519 (HY-50940) based Cyclin K degrader with DC50 of 21 nM. Cyclin K degrader 1 has an affinity for cyclin K that is ~500-fold higher than its affinity for CDK12[1].

Product Specifications

UNSPSC

12352005

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cyclin-k-degrader-1.html

Purity

99.86

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=NNC=C1NC(C2=C(Cl)C=CC=C2Cl)=O)NCC3=CC=C(C=C3)C4=CC=CC=N4

Molecular Formula

C23H17Cl2N5O2

Molecular Weight

466.32

References & Citations

[1]Thomas KL, et al., Degradation by Design: New Cyclin K Degraders from Old CDK Inhibitors. ACS Chem Biol. 2024 Jan 19;19 (1) :173-184. doi: 10.1021/acschembio.3c00616