Cyclin K degrader 1
Cyclin K degrader 1 (compound 40) is an AT7519 (HY-50940) based Cyclin K degrader with DC50 of 21 nM. Cyclin K degrader 1 has an affinity for cyclin K that is ~500-fold higher than its affinity for CDK12[1].
Product Specifications
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cyclin-k-degrader-1.html
Purity
99.86
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=NNC=C1NC(C2=C(Cl)C=CC=C2Cl)=O)NCC3=CC=C(C=C3)C4=CC=CC=N4
Molecular Formula
C23H17Cl2N5O2
Molecular Weight
466.32
References & Citations
[1]Thomas KL, et al., Degradation by Design: New Cyclin K Degraders from Old CDK Inhibitors. ACS Chem Biol. 2024 Jan 19;19 (1) :173-184. doi: 10.1021/acschembio.3c00616
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
LV704410 1.0 µg DNA
DOCK8 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-C-term-HA)
Sign In for Pricing
View Details 
MBS6422368-01 0.1 mL
IL10 (Interleukin-10, CSIF, GVHDS, IL-10, IL10A, TGIF, Cytokine Synthesis Inhibitory Factor) (MaxLight 650)
Sign In for Pricing
View Details