CHI3L1-IN-1
CHI3L1-IN-1 (Compound 30) is an inhibitor for Chitinase-3-like protein 1 (CHI3L1) (YKL-40) with IC50 of 50 nM. CHI3L1-IN-1 inhibits hERG channel with an IC50 of 2.3 μM[1].
Product Specifications
CAS Number
2982256-78-8
UNSPSC
12352005
Target
Glycosidase; Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/chi3l1-in-1.html
Purity
99.68
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C[C@H](OC1)CN(C2CCN(C3=CC(Cl)=CC=N3)CC2)[C@H]1CC4=CC=C(C=C4)Cl
Molecular Formula
C22H27Cl2N3O
Molecular Weight
420.38
References & Citations
[1]Czestkowski W, et al., Structure-Based Discovery of High-Affinity Small Molecule Ligands and Development of Tool Probes to Study the Role of Chitinase-3-Like Protein 1. J Med Chem. 2024 Mar 14;67 (5) :3959-3985.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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