Dehydroglyasperin C

Dehydroglyasperin C, a isoflavone, is a potent NAD (P) H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C has antioxidant, neuroprotective, cancer chemopreventive, and anti-inflammatory activities[1][2][3].

Product Specifications

CAS Number

[199331-35-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Others; Quinone Reductase

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dehydroglyasperin-c.html

Purity

99.12

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=CC=C(C2=CC3=C(OC)C(C/C=C(C)\C)=C(O)C=C3OC2)C(O)=C1

Molecular Formula

C21H22O5

Molecular Weight

354.40

Precautions

H302, H315, H319, H335

References & Citations

[1]Hyo Jung Kim, et al. Dehydroglyasperin C, a component of liquorice, attenuates proliferation and migration induced by platelet-derived growth factor in human arterial smooth muscle cells. Br J Nutr. 2013 Aug 28;110 (3) :391-400.|[2]Ji Hoon Lee, et al. Dehydroglyasperin C suppresses TPA-induced cell transformation through direct inhibition of MKK4 and PI3K. Mol Carcinog. 2016 May;55 (5) :552-62.|[3]Ji Yeon Seo, et al. Dehydroglyasperin C isolated from licorice caused Nrf2-mediated induction of detoxifying enzymes. J Agric Food Chem. 2010 Feb 10;58 (3) :1603-8.|[4]Seo, J.Y, et al. Protective effects of dehydroglyasperin c against carbon tetrachloride-induced liver damage in mice. Food Sci Biotechnol 23, 547–553 (2014) .