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DHFR-IN-3

DHFR-IN-3 is a dihydrofolate reductase (DHFR) inhibitor with the IC50 values of 19 μM and 12 μM in rat liver and P. carinii DHFR, respectively[1].

Product Specifications

CAS Number

137553-43-6

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antifolate; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/dhfr-in-3.html

Concentration

10mM

Purity

99.76

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NC1=NC(N)=C2C=CC(Br)=CC2=N1

Molecular Formula

C8H7BrN4

Molecular Weight

239.08

Precautions

H302, H315, H319, H335

References & Citations

[1]A Rosowsky, et al. Structure-activity and structure-selectivity studies on diaminoquinazolines and other inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase. Antimicrob Agents Chemother. 1995 Jan;39 (1) :79-86.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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