DHFR-IN-3
DHFR-IN-3 is a dihydrofolate reductase (DHFR) inhibitor with the IC50 values of 19 μM and 12 μM in rat liver and P. carinii DHFR, respectively[1].
Product Specifications
CAS Number
[137553-43-6]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antifolate; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/dhfr-in-3.html
Concentration
10mM
Purity
99.76
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=NC(N)=C2C=CC(Br)=CC2=N1
Molecular Formula
C8H7BrN4
Molecular Weight
239.08
Precautions
H302, H315, H319, H335
References & Citations
[1]A Rosowsky, et al. Structure-activity and structure-selectivity studies on diaminoquinazolines and other inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase. Antimicrob Agents Chemother. 1995 Jan;39 (1) :79-86.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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