(S) -Retosiban
(S) -Retosiban is the isomer of Retosiban (HY-14778), and can be used as an experimental control. Retosiban (GSK221149A) is a potent and selective oxytocin antagonist with a Ki of 0.65 nM.
Product Specifications
CAS Number
[2994298-20-1]
Product Name Alternative
(S) -GSK 221149; (S) -GSK 221149A
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Oxytocin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/s-retosiban.html
Purity
99.12
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C([C@@H](C1CC2=C(C=CC=C2)C1)N3)N([C@@H](C4=COC(C)=N4)C(N5CCOCC5)=O)[C@H]([C@H](CC)C)C3=O
Molecular Formula
C27H34N4O5
Molecular Weight
494.58
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Liddle J, et al. The discovery of GSK221149A: a potent and selective oxytocin antagonist. Bioorg Med Chem Lett. 2008 Jan 1;18 (1) :90-4.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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